Enhancing Vaccine Efficacy Against Staphylococcus Aureus Infections Using Glycoside Hydrolases
DOI:
https://doi.org/10.70088/1m1xxh25Keywords:
staphylococcus aureus, vaccine, biofilm, glycoside hydrolases, protein expressionAbstract
Staphylococcus aureus is one of the most clinically significant Gram-positive bacterial pathogens, frequently colonizing the skin, nasal cavity, throat, and gastrointestinal tract of humans and animals. It is a leading cause of abscesses, purulent infections, and severe systemic diseases worldwide. Although vaccination represents a promising prophylactic strategy, the formation of bacterial biofilms poses a formidable barrier that prevents vaccine candidates from accessing target antigens on the bacterial surface. To address this challenge, this study investigates the potential of glycoside hydrolases, particularly PelA, as enzymatic agents capable of degrading biofilm matrices and thereby exposing hidden antigens to the immune system. Collectively, following with the past articles. Those findings suggest that PelA-mediated biofilm degradation may enhance antigen accessibility and improve immune recognition. This study provides a mechanistic foundation for integrating glycoside hydrolases into vaccine development strategies and offers a potential approach for overcoming biofilm-associated barriers in Staphylococcus aureus immunization.References
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Copyright (c) 2026 Jiajun Yu (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
