Epigenetic Profiling of Peripheral Blood Mononuclear Cells in Patients with Early-Onset Alzheimer's Disease
DOI:
https://doi.org/10.70088/edp6eh30Keywords:
Epigenetics, Peripheral Blood Mononuclear Cells, Early-Onset Alzheimer's Disease, Biomarkers, NeurodegenerationAbstract
This research article afterward investigates the profiling of blood mononuclear cells (PBMCs) in patients diagnosed with -onslaught Alzheimer's disease (EOAD). The survey essentially aims to place specific epigenetic modification and their likely part in disease progression. Expend advanced sequence techniques. The enquiry explores DNA methylation patterns and histone modifications in PBMCs. Liken to hefty control, results unveil epigenetic signature in EOAD patients, propose potential biomarkers for former diagnosing and therapeutic targets. To understand the molecular mechanisms underlie EOAD. The determination contribute and accentuate the grandness of epigenetic ordinance in diseases.References
M. Owczarz, J. Połosak, A. Domaszewska-Szostek, P. Kołodziej, A. Kuryłowicz, and M. Puzianowska-Kuźnicka, "Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells," Epigenetics, vol. 15, no. 12, pp. 1336-1347, 2020.
A. Di Francesco, B. Arosio, A. Falconi, M. V. M. Di Bonaventura, M. Karimi, D. Mari, et al., "Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells," Brain Behav. Immun., vol. 45, pp. 139-144, 2015.
S. Luo, G. Liang, P. Zhang, M. Zhao, and Q. Lu, "Aberrant histone modifications in peripheral blood mononuclear cells from patients with Henoch--Schönlein purpura," Clin. Immunol., vol. 146, no. 3, pp. 165-175, 2013.
O. Kaut, I. Schmitt, J. Tost, F. Busato, Y. Liu, P. Hofmann, et al., "Epigenome-wide DNA methylation analysis in siblings and monozygotic twins discordant for sporadic Parkinson's disease revealed different epigenetic patterns in peripheral blood mononuclear cells," Neurogenetics, vol. 18, no. 1, pp. 7-22, 2017.
D. P. Gavin and R. P. Sharma, "Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia," Cardiovasc. Psychiatry Neurol., vol. 2009, no. 1, p. 409562, 2009.
L. Lam, L. Chin, R. C. Halder, B. Sagong, S. Famenini, J. Sayre, et al., "Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients," FASEB J., vol. 30, no. 10, p. 3461, 2016.
C. Shu, X. Zhang, B. E. Aouizerat, and K. Xu, "Comparison of methylation capture sequencing and Infinium MethylationEPIC array in peripheral blood mononuclear cells," Epigenetics Chromatin, vol. 13, no. 1, p. 51, 2020.
N. Yan, J. Z. Zhou, J. A. Zhang, T. Cai, W. Zhang, Y. Wang, et al., "Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease," Mol. Cell. Endocrinol., vol. 414, pp. 143-147, 2015.
A. Arita, J. Niu, Q. Qu, N. Zhao, Y. Ruan, A. Nadas, et al., "Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel," Environ. Health Perspect., vol. 120, no. 2, p. 198, 2011.
B. Arosio, C. D′ Addario, C. Gussago, M. Casati, E. Tedone, E. Ferri, et al., "Peripheral blood mononuclear cells as a laboratory to study dementia in the elderly," BioMed Res. Int., vol. 2014, no. 1, p. 169203, 2014.
Y. Li, J. Zhu, G. Tian, N. Li, Q. Li, M. Ye, et al., "The DNA methylome of human peripheral blood mononuclear cells," PLoS Biol., vol. 8, no. 11, p. e1000533, 2010.
P. Bompada, I. Goncalves, C. Wu, R. Gao, J. Sun, B. A. Mir, et al., "Epigenome-wide histone acetylation changes in peripheral blood mononuclear cells in patients with type 2 diabetes and atherosclerotic disease," Biomedicines, vol. 9, no. 12, p. 1908, 2021.
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Copyright (c) 2025 Xiaoyu Chen (Author)
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