Integrated Traditional Chinese and Western Medicine Prevention and Treatment of Diabetic Male Sexual Dysfunction Based on the "Kidney Stores Essence" Theory in Huangdi Neijing
DOI:
https://doi.org/10.70088/cb45ye45Keywords:
Huangdi Neijing, kidney stores essence, wasting-thirst disease, diabetes mellitus, male sexual dysfunction, integrated traditional Chinese and Western medicine, preventive treatment of diseaseAbstract
Diabetic male sexual dysfunction is a common chronic complication of type 2 diabetes mellitus, mainly manifested as decreased libido, erectile dysfunction and ejaculatory disorders. Simple symptomatic intervention with Western medicine can hardly reverse the damage to gonads, blood vessels and nerves fundamentally, accompanied by limitations such as poor long-term efficacy and prominent adverse reactions. Huangdi Neijing establishes the core theory of "kidney stores essence", proposing that the kidney governs reproduction and kidney essence serves as the foundation of reproductive function. Meanwhile, it fully elaborates the pathological chain of metabolic disorders consuming kidney essence through the discussions on "wasting-thirst disease" and "spleen-dampness disease". Taking the theory of "kidney stores essence" as the main line, this paper combines modern endocrinological and andrological clinical studies, integrates the theories of seasonal health preservation, preventive treatment of disease and staged syndrome differentiation recorded in Huangdi Neijing, sorts out the integrated Chinese and Western pathological mechanisms of diabetic sexual dysfunction, and constructs an integrated prevention and treatment scheme of "stabilizing blood glucose to consolidate the root, tonifying the kidney and replenishing essence, and staged conditioning". Studies have demonstrated that synergistic intervention of integrated Chinese and Western medicine can stabilize blood glucose, repair vascular and nerve injuries, improve sex hormone secretion, invigorate the spleen and kidney, soothe the liver and activate blood to consolidate kidney essence. It can block reproductive injuries in the prediabetic stage in advance, delay sexual function decline in the middle and late stages, and provide theoretical basis of traditional Chinese medicine and feasible clinical approaches for standardized full-cycle prevention and treatment of this disease.References
Z. A. Kamenov, "A comprehensive review of erectile dysfunction in men with diabetes," Exp. Clin. Endocrinol. Diabetes, vol. 123, no. 3, pp. 141–158, 2015.
G. Hackett, N. Cole, A. Saghir, P. Jones, R. C. Strange, and S. Ramachandran, "Testosterone undecanoate improves sexual function in men with type 2 diabetes and severe hypogonadism: results from a 30‐week randomized placebo‐controlled study," BJU Int., vol. 118, no. 5, pp. 804–813, 2016.
M. L. Isidro, "Sexual dysfunction in men with type 2 diabetes," Postgrad. Med. J., vol. 88, no. 1037, pp. 152–159, 2012.
J. Ma, Y. Chen, Y. Si, J. Qian, C. Wang, J. Jin, and Q. He, "The multifaceted nature of diabetic erectile dysfunction: uncovering the intricate mechanisms and treatment strategies," Front. Endocrinol., vol. 15, p. 1460033, 2024.
S. Hylmarova, K. Stechova, G. Pavlinkova, J. Peknicova, M. Macek, and M. Kvapil, "The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels," Endocr. J., vol. 67, no. 1, pp. 59–71, 2020.
L. S. Malavige and J. C. Levy, "Erectile dysfunction in diabetes mellitus," J. Sex. Med., vol. 6, no. 5, pp. 1232–1247, 2009.
Y. Kouidrat, D. Pizzol, T. Cosco, T. Thompson, M. Carnaghi, A. Bertoldo, et al., "High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies," Diabet. Med., vol. 34, no. 9, pp. 1185–1192, 2017.
D. Dilixiati, A. Waili, A. Tuerxunmaimaiti, L. Tao, A. Zebibula, and M. Rexiati, "Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis," Front. Endocrinol., vol. 15, p. 1368079, 2024.
G. Defeudis, R. Mazzilli, M. Tenuta, G. Rossini, V. Zamponi, S. Olana, et al., "Erectile dysfunction and diabetes: a melting pot of circumstances and treatments," Diabetes Metab. Res. Rev., vol. 38, no. 2, p. e3494, 2022.
A. Basu and R. E. Ryder, "New treatment options for erectile dysfunction in patients with diabetes mellitus," Drugs, vol. 64, no. 23, pp. 2667–2688, 2004.
A. E. Weinberg, M. Eisenberg, C. J. Patel, G. M. Chertow, and J. T. Leppert, "Diabetes severity, metabolic syndrome, and the risk of erectile dysfunction," J. Sex. Med., vol. 10, no. 12, pp. 3102–3109, 2013.
G. Defeudis, D. Gianfrilli, C. Di Emidio, R. Pofi, D. Tuccinardi, A. Palermo, et al., "Erectile dysfunction and its management in patients with diabetes mellitus," Rev. Endocr. Metab. Disord., vol. 16, no. 3, pp. 213–231, 2015.
N. H. Cho, C. W. Ahn, J. Y. Park, T. Y. Ahn, H. W. Lee, T. S. Park, et al., "Prevalence of erectile dysfunction in Korean men with Type 2 diabetes mellitus," Diabet. Med., vol. 23, no. 2, pp. 198–203, 2006.
D. Tamrakar, D. S. Bhatt, V. K. Sharma, A. K. Poudyal, and B. K. Yadav, "Association between erectile dysfunction and type 2 diabetes mellitus," J. Sex. Med., 2021.
G. Corona, E. Mannucci, R. Mansani, L. Petrone, M. Bartolini, R. Giommi, et al., "Organic, relational and psychological factors in erectile dysfunction in men with diabetes mellitus," Eur. Urol., vol. 46, no. 2, pp. 222–228, 2004.
J. Hidalgo-Tamola and K. Chitaley, "Type 2 diabetes mellitus and erectile dysfunction," J. Sex. Med., vol. 6, no. 4, pp. 916–926, 2009.
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Copyright (c) 2026 Xuanji Zhang, Jialin Ren, Hongxia Su (Author)
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