Exploration on the Modern Application and Value of Traditional Chinese Medicine Theories for Cerebrovascular Disease Prevention and Treatment Based on the Doctrine "All Wind, Tremor and Vertigo Are Associated with the Liver"

Authors

  • Yanli Liu Shaanxi University of Chinese Medicine, Xianyang, China Author
  • Ziyan Liu Shaanxi University of Chinese Medicine, Xianyang, China Author

DOI:

https://doi.org/10.70088/h5bhr108

Keywords:

Huangdi Neijing, internal stirring of liver wind, cerebrovascular diseases, integrative medicine, liver-yin deficiency

Abstract

Objective To unpack the core connotation of the classical pathogenetic doctrine "All wind, tremor and vertigo are associated with the liver" recorded in Huangdi Neijing (Huangdi's Internal Classic), and systematically explore the clinical value of this Traditional Chinese Medicine (TCM) theory across the full spectrum of cerebrovascular disease prevention, intervention and rehabilitation, as well as its theoretical intersections with integrative Chinese and Western medicine. Methods This study adopted literature retrieval, tracing of theoretical origins, and comparative analysis of TCM and biomedical theories. We systematically summarized the original pathogenesis, syndrome categorization, and diagnostic-treatment logic of the liver-wind doctrine, and interpreted its intrinsic links with cerebrovascular disorders combined with clinical guidelines and global research evidence. Results This doctrine identifies internal stirring of liver wind as the core pathogenesis of cerebrovascular diseases, and clarifies liver yin-yang and qi-blood imbalance as the root cause of cerebral vascular injury. Derived therapeutic strategies align closely with mainstream biomedical interventions including blood pressure regulation, neuroprotection and neural remodeling, and compensate for biomedicine's deficiency in holistic regulation. Conclusion Validated by millennia of clinical practice, this doctrine has high practical value in modern cerebrovascular care. Its integration with modern research can optimize staged prevention and treatment systems and elevate the overall rehabilitation level of cerebrovascular patients.

References

T. Liu, M. Qin, et al., "Multi-omics approaches for deciphering the complexity of traditional Chinese medicine syndromes in stroke: A systematic review," Frontiers in Pharmacology, vol. 13, p. 980650, 2022.

L. Wang, Y. Wang, Y. Chen, B. Liu, D. Chou, X. Bian, R. Li, M. Wang, and C. Zheng, "Rhynchophylline ameliorates cerebral ischemia by improving the synaptic plasticity in a middle cerebral artery occlusion induced stroke model," European Journal of Pharmacology, vol. 940, p. 175390, 2023.

J. W. Xian, A. Y. T. Choi, C. B. S. Lau, W. N. Leung, C. F. Ng, and C. W. Chan, "Gastrodia and Uncaria (tianma gouteng) water extract exerts antioxidative and antiapoptotic effects against cerebral ischemia in vitro and in vivo," Chinese Medicine, vol. 11, no. 1, p. 27, 2016.

L. Chen, Y. Liu, and J. Xie, "The beneficial pharmacological effects of Uncaria rhynchophylla in neurodegenerative diseases: focus on alkaloids," Frontiers in Pharmacology, vol. 15, p. 1436481, 2024.

H. Huang, R. Zhong, Z. Xia, J. Song, and L. Feng, "Neuroprotective effects of rhynchophylline against ischemic brain injury via regulation of the Akt/mTOR and TLRs signaling pathways," Molecules, vol. 19, no. 8, pp. 11196–11210, 2014.

X. Fan, H. Li, J. Liu, Y. Lin, L. Sun, B. Liu, W. Zhao, Y. Yu, H. Zhang, M. Wang, and X. Teng, "The Tianma Anshen Dingxuan Formula Regulates Gut Microbiota and Metabolites in a Rat Model of Vertigo With Liver Yang Hyperactivity," Phytochemical Analysis, vol. 37, no. 1, pp. 100–116, 2026.

Y. Qin, S. Hu, S. Mawen, S. Pan, Y. Huai, G. Liang, T. Chen, F. Zhao, H. Dong, X. Yao, and X. Wu, "Neuroprotective mechanisms of Buyang Huanwu decoction in ischemic stroke," Frontiers in Pharmacology, vol. 16, p. 1620533, 2025.

K. Lee, H. Joo, M. Sun, M. Kim, B. Kim, B. J. Lee, J. H. Cho, J. Y. Jung, J. W. Park, and Y. Bu, "Review on the characteristics of liver-pacifying medicinal in relation to the treatment of stroke: from scientific evidence to traditional medical theory," Journal of Traditional Chinese Medicine, vol. 38, no. 1, pp. 139–150, 2018.

Z. Liu, Z. Han, W. Bao, Y. Guo, Y. Yuan, J. Cheng, J. Zhang, and Y. Hu, "Gastrodin Attenuates Cerebral Ischemia--Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the AMPK‐OPA1 Signaling Pathway," CNS Neuroscience & Therapeutics, vol. 31, no. 8, p. e70559, 2025.

J. Fang, L. Chen, R. Ma, C. L. Keeler, L. Shen, Y. Bao, and S. Xu, "Comprehensive rehabilitation with integrative medicine for subacute stroke: a multicenter randomized controlled trial," Scientific Reports, vol. 6, no. 1, p. 25850, 2016.

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Published

05 August 2026

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How to Cite

Liu, Y. and Liu, Z. (2026) “Exploration on the Modern Application and Value of Traditional Chinese Medicine Theories for Cerebrovascular Disease Prevention and Treatment Based on the Doctrine ‘All Wind, Tremor and Vertigo Are Associated with the Liver’”, Medicine Insights, 3(3), pp. 79–88. doi:10.70088/h5bhr108.