Cerebral Infarction Following Bee Sting: A Case Report and Literature Review
DOI:
https://doi.org/10.70088/fs6hj236Keywords:
bee sting, cerebral infarction, ischaemic stroke, anaphylaxis, hypercoagulabilityAbstract
Bee stings typically cause local or systemic allergic reactions, but secondary cerebral infarction is an exceedingly rare complication. We report a 65‐year‐old man who developed motor aphasia and right‐sided hemiplegia approximately 19 hours after being stung by bees on the left forehead and left upper arm. Imaging revealed a new acute infarct in the left frontotemporal lobe and basal ganglia, superimposed on severe pre‐existing left internal carotid artery stenosis. Laboratory tests showed elevated fibrinogen and D‐dimer, indicating a hypercoagulable state. After antiplatelet therapy, lipid‐lowering statin treatment, and comprehensive rehabilitation, the patient was left with persistent right‐sided motor dysfunction and aphasia. We review the 25 previously reported cases and discuss potential mechanisms, including systemic inflammation, hypercoagulability, allergy‐related hypotension, vasoconstriction mediated by vasoactive substances, and sympathetic dysregulation. This case underscores that bee stings can act as a significant trigger for ischaemic stroke in patients with underlying cerebrovascular stenosis, and clinicians should maintain a high index of suspicion when neurological symptoms emerge after envenomation.References
X. Y. Wang, L. L. Zhao, M. Y. Geng, et al., "Research progress on main components and pharmacological effects of bee venom," Zhongguo Feng Ye (Apiculture of China), vol. 75, no. 1, pp. 50–52, 2024.
R. E. Reisman, "Unusual reactions to insect stings," Curr. Opin. Allergy Clin. Immunol., vol. 5, no. 4, pp. 355–358, 2005.
L. Chen, G. Z. Huang, and Y. J. Xu, "Acute renal failure after bee sting: an autopsy case report," Fa Yi Xue Za Zhi (Journal of Forensic Medicine), no. 1, pp. 36–37, 1997.
X. W. Wu and Y. Tian, "Identification of a death due to anaphylactic shock caused by bee venom poisoning," Zhongguo Fa Yi Xue Za Zhi (Chinese Journal of Forensic Medicine), vol. 37, no. 2, pp. 205+208, 2022.
J. H. Lee, M. J. Kim, Y. S. Park, et al., "Severe systemic reactions following bee sting injuries in Korea," Yonsei Med. J., vol. 64, no. 6, pp. 404–412, 2023.
R. W. Chen, H. S. Di Liang, F. F. Chen, et al., "Sudden demise after hornet envenomation: a dual case report," Rom. J. Leg. Med., vol. 33, pp. 124–127, 2025.
S. Yang, J. Wellington, J. Chen, et al., "Cerebral infarction following bee stings: case report and literature review," Transl. Neurosci., vol. 13, no. 1, pp. 163–171, 2022.
J. E. Riggs, L. M. Ketonen, J. P. Wymer, et al., "Acute and delayed cerebral infarction after wasp sting anaphylaxis," Clin. Neuropharmacol., vol. 17, no. 4, pp. 384–389, 1994.
M. Wani, S. Saleem, S. Verma, et al., "Multiple cerebral infarctions with severe multi‐organ dysfunction following multiple wasp stings," Ann. Indian Acad. Neurol., vol. 17, no. 1, pp. 125–127, 2014.
M. R. Vidhate, P. Sharma, R. Verma, et al., "Bilateral cavernous sinus syndrome and bilateral cerebral infarcts: a rare combination after wasp sting," J. Neurol. Sci., vol. 301, no. 1–2, pp. 104–106, 2011.
F. Crawley, F. Schon, and M. Brown, "Cerebral infarction: a rare complication of wasp sting," J. Neurol. Neurosurg. Psychiatry, vol. 66, no. 4, p. 550, 1999.
A. Sachdev, M. Mahapatra, S. D'Cruz, et al., "Wasp sting induced neurological manifestations," Neurol. India, vol. 50, no. 3, pp. 319–321, 2002.
J. E. Riggs, L. M. Ketonen, J. B. Bodensteiner, et al., "Wasp sting‐associated cerebral infarction: a role for cerebrovascular sympathetic innervation," Clin. Neuropharmacol., vol. 16, no. 4, pp. 362–365, 1993.
J. Jain, S. Banait, A. K. Srivastava, et al., "Stroke intracerebral multiple infarcts: rare neurological presentation of honey bee bite," Ann. Indian Acad. Neurol., vol. 15, no. 2, pp. 163–166, 2012.
J. S. Schiffman, R. A. Tang, E. Ulysses, et al., "Bilateral ischaemic optic neuropathy and stroke after multiple bee stings," Br. J. Ophthalmol., vol. 88, no. 12, pp. 1596–1598, 2004.
A. Kulhari, A. Rogers, H. Wang, et al., "Ischemic stroke after wasp sting," J. Emerg. Med., vol. 51, no. 4, pp. 405–410, 2016.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Yongping Wei, Cenxuelun Zhang (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.









