Study on the Improvement of Contextual Memory in Patients with Early-Stage AD via AI-Driven Adaptive Dietary-Exercise Combined Intervention
DOI:
https://doi.org/10.70088/zj8mxr19Keywords:
Alzheimer's disease, episodic memory, dietary intervention, exercise intervention, artificial intelligence, dynamic adaptationAbstract
Objective: To investigate the efficacy of a combined diet-and-exercise intervention, utilizing wearable devices and AI-driven dynamic adaptation technology, in improving episodic memory function in patients with early-stage Alzheimer's disease (AD). Methods: A randomized controlled trial design was employed. A total of 120 patients with early-stage AD who visited multiple medical institutions in Chongqing between March 2025 and March 2026 were enrolled and randomly assigned via a random number table to either an intervention group (n=60) or a control group (n=60). The control group received a conventional health management program, whereas the intervention group received, in addition to the control group's program, a combined diet-and-exercise intervention incorporating data acquisition via wearable devices and an AI-based dynamic optimization algorithm; the intervention duration was 12 weeks. Results: After the intervention, the intervention group showed an increase in the EMS score of (3.82±1.15) points compared to baseline, which was significantly greater than that of the control group [(1.26±0.98) points] (t=16.873, P<0.001). The intervention group also demonstrated improvements in the MMSE score (2.45±0.87 points) and the MoCA score (2.18±0.76 points), both of which were significantly superior to those of the control group (P<0.001). Furthermore, the improvement in the ADL score in the intervention group was also greater than that in the control group (P<0.05). The incidence of adverse events was 5.0% in the intervention group and 6.7% in the control group, with no statistically significant difference (P>0.05). Conclusion: The combined diet-and-exercise intervention, leveraging wearable devices and AI-driven dynamic adaptation, can significantly enhance episodic memory function in patients with early-stage AD. This intervention demonstrates superior efficacy compared to conventional health management protocols and holds potential for widespread clinical application.References
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